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Also, because GLP-1 drugs engage the brain’s reward circuitry – the same system that governs not just craving but everyday motivation – prolonged use could, in theory, dampen motivational drive in some people. Whether that might affect real-world outcomes, such as initiative, competitive drive or performance at work, remains an open question. https://www.youtube.com/embed/KGPjLopNvOU?wmode=transparent&start=0 Mounting research – as well as real-life success stories – paints a bright future for the use of GLP-1 drugs in addiction treatment.